Reduced gamma-aminobutyric acid (GABA) inhibition has been implicated in both anxiety and epilepsy.GAD65-/- (NOD/LtJ) mice have significantly decreased basal GABA levels in the brain and a lowered threshold for seizure generation.One fifth of GAD65 -/- mice experienced stress-induced seizures upon exposure to an open field at 4 weeks of age.In each
Aerobes require oxygen for metabolism and normal free radical formation.As a result, maintaining the redox homeostasis is essential for brain cell survival due to their high metabolic energy requirement to sustain electrochemical gradients, neurotransmitter release, and membrane lipid stability.Further, brain antioxidant levels are limited compared
Objective To predict the cost and health effects of routine use of whole-genome sequencing (WGS) of bacterial pathogens compared with those of standard of care.Design Budget impact analysis was performed over the following 5 years.Data were primarily from sequencing results on clusters of multidrug-resistant organisms across 27 hospitals.Model inpu
Image processing is widely used in intelligent robots, significantly improving the surveillance capabilities of smart buildings, industrial parks, and border ports.However, relying on Yoghurt Pouch the camera installed in a single robot is not enough since it only provides a narrow field of view as well as limited processing performance.Specially,
IntroductionTuberculosis (TB) still kills over 1 million people annually.The only approved vaccine, BCG, prevents disseminated disease in children but shows low efficacy at preventing pulmonary TB.Myeloid dendritic cells (mDCs) are promising targets for vaccines and immunotherapies to combat infectious diseases due to their essential role in linkin